A Student's Question...
How can The Human Genome Project help find a CURE for Parkinson's?

(see credit at bottom) [ Common Fruit Fly ]

Drosophila: a fly geneticist's swiss army knife
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Topic 10A: a student's question
This site contains education and research URL's bookmarked by a Parkinson's patient. Nothing you read in these pages should be considered an endorsement or medical advice.


> Saturday, Dec. 14th. 2002
>
> Hi Mr. Charters,
>
> My name is xxxx and I am an OAC student
> at Thornlea Secondary School.
>
> I am researching how the human genome project
> will help find a cure for Parkinson's disease.
>
> I would really appriciate it if you can give
> me any information on this subject.
>
> Thank you very much,
> xxxx

Good Morning xxxx,

Let's see... OAC student at TSS...

The Ontario Education system includes
the "OAC" year.

OAC stands for Ontario Academic Credit,
of which you need 6 to enter university.

Sooo... you must be a Grade 12/OAC student
working on your University Entrance...

will you be going to Queens? Neurobiology?
(do they have neurobiology at Queens?)

Thornlea Secondary School
8075 Bayview Avenue
Thornhill, Ontario L3T 4N4
Phone: (905) 889-9696
Facsimile number: (905) 889-2991
http://www.thornlea.ca/

Thornhill is a community of about 100,000 persons
just on the north end of Toronto...

my aunt lived in Orillia...

I'm a 58 year old elevator / escalator mechanic
who has Parkinson's...

I still work every day...

We live in Vancouver, BC

I have a web site...

Welcome to Parkinson's Resources!
Dedicated to Parkinson's Awareness
& FREE Easy Access to "Information" for All


and it has a Parkinson's & Human Genome Project page...
010.html

but... you must have seen that or you
wouldn't have asked for my input...

Read this "backgrounder" first...
The Decade of the Brain : A Brief Review
http://www.neurologyindia.com/vol48-3/ra63.pdf

(requires Adobe Acrobat reader...)
http://www.adobe.com/products/acrobat/...

There was a mutation in the Alpha Synuclein gene...

Gretchen, Vogel, Gene discovery offers tentative
clues to Parkinsonís, Science, 06/27/97,
Vol 276 Issue 5321, p1973, 1p 1c.

Polymeropoulos, Michael H, et al., Mutation in
the a-Synuclein Gene Identified in Families
with Parkinsonís Disease, Science, 06/27/97,
Vol 276 Issue 5321, p2045-47, 3p.

http://www.sciencemag.org/content/

SCIENCE Online wants you to Sign In... AND PAY!

That sucks... Want the same thing FREE?

Yah! ....

if you go back to ...
010.html

and click on...

Genes and Disease
http://www.ncbi.nlm.nih.gov/disease/

you can follow this wealth of information...

click on...
http://www.ncbi.nlm.nih.gov/disease/Brain.html

click on...
http://www.ncbi.nlm.nih.gov/disease/Parkinson.html


http://www.nhgri.nih.gov/DIR/LGDR/PARK2/

"Researchers from the National Human Genome Research
Institute in Maryland have discovered a gene called
alpha-synuclein that is the possible foundation
in a heredity form of Parkinsonís."

go to ...
http://a-s.clayton.edu/hampikian/...

and click on...
Carpenter, Caryn
Gene discovery offers tentative clues to Parkinson's
http://a-s.clayton.edu/hampikian/1901H/

http://www.lancetneuronet.com/registration

Registration is completely FREE
and provides the following benefits:

Unlimited search facilities
Free access to selected full-text articles
'Pay per view' article access
Free access to the Electronic Research Archive (ERA)
Free full-text global news
A wide range of subscription options

Once you have registered to THE LANCET
Publishing Group you do not need to
register again.

http://www.lancetneuronet.com/journal/vol1/iss5/contents

http://www.lancetneuronet.com/...


Search Lancet for "parkinson" AND "gene"
http://www.lancetneuronet.com/search

ahhh! 24 hits... full text available...

Shaking the Family Tree:
Discovery of Familial Parkinson's Disease Gene

The Genetics of Parkinson's Disease

Can 18F-Fluorodopa Positron Emission
Tomography Help Determine Disease Status
in Familial Parkinson's Disease?

Motor Circuits and Dystonia

Tuberous Sclerosis: Endocytosis
and Growth Regulation

Functional Imaging of Brain Mechanisms
in Dopa-Induced Dyskinesia

Nerve Growth Factor Gene Transfer
to the Aging Brain:
A Role in Preventing Dementia?

A Possible Mouse Model of Huntington's Disease

Pallidotomy: Refining the technique

Alzheimer's Disease Pathology and Genetics

The Broadening Image of ALS:
Discovery of New Mutations

Identifies Clinical Phenotypes

Clinical and Pathological Variability
and Similarity in Degenerative Disease
With P301L Tau Mutations

Pallidotomy for Dystonia:
Why Should It Work?

Rebuilding the brain from postmortem tissue:
do we have the needed insights and technology?

Apolipoprotein E
and the Diagnosis of Alzheimer's Disease

Radiological onset and progression
of autosomal dominant Alzheimer's disease

The Elusive Heredity of Tourette Syndrome

Imaging the Limbic System:
Clinical Implications

Treatment of Restless Legs Syndrome

Therapy for ALS

and all free...

are you "swamped" yet?

The above articles are great but...
they're typically a coupla years old...

go to my VIP page...
vip.html

click on... PhRMA Genomics Today

PhRMA Genomics Today
http://genomics.phrma.org/today/

click on... Human Genome Project

Genetics in the News
http://www.ornl.gov/hgmis/archive/headlines.html

Genetic Disease Information --pronto!
http://www.ornl.gov/hgmis/medicine/assist.html

Genomic News Network
http://gnn.tigr.org/main.shtml

Genetics and Genomics Timeline
http://gnn.tigr.org/timeline/timeline_home.shtml

Thomas Hunt Morgan, an embryologist who had turned to research in heredity, in 1907 began to extensively breed the common fruit fly, Drosophila melanogaster. He hoped to discover large-scale mutations that would represent the emergence of new species. As it turned out, Morgan confirmed Mendelian laws of inheritance and the hypothesis that genes are located on chromosomes. He thereby inaugurated classical experimental genetics.
http://gnn.tigr.org/timeline/1910_Morgan.shtml

What's a Genome?
http://gnn.tigr.org/whats_a_genome/Chp1_1_1.shtml

A Quick Guide to Sequenced Genomes
http://gnn.tigr.org/sequenced_genomes/

The Other Human Genome
Mitochondria are the focus of new research
on Alzheimerís, Parkinsonís and diabetes
http://gnn.tigr.org/articles/04_02/mito_dna.shtml

Human genome search implicates multiple genes in Parkinsonís
http://exploration.vanderbilt.edu/news/

Human Genome Research Implicates Genes in Parkinson's
http://my.webmd.com/content/article/

The National Human Genome Research Institute (NHGRI) created the Talking Glossary of Genetic Terms to help people without scientific backgrounds understand the terms and concepts used in genetic research. Simply click on the term of interest to open a page with a wealth of information, including the term's pronunciation, audio information, images and additional links to related terms. Students, teachers and parents will find the glossary an easy-to-use, always available learning source on genetics.
Talking Glossary of Genetic Terms

Guide to the Talking Glossary of Genetics
http://www.genome.gov/page.cfm?pageID=10003803

Search PubMed for "genome AND parkinson"
http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?

MEDLINEplus Latest Parkinson's News
http://www.nlm.nih.gov/medlineplus/

Subject Index of Text Prepared for Human Genome News - 1995 to Present
http://www.ornl.gov/hgmis/publicat/hgn/hgnarch.html

Introduction to the Human Genome Project
http://www.genome.gov/page.cfm?pageID=10001772

Online Genetics Resources for Educators and Students
http://www.genome.gov/page.cfm?pageID=10000464

Welcome to the Human Genome Project, "Exploring Our Molecular Selves" online multimedia educational kit.
http://www.genome.gov/Pages/Hyperion/educationkit/...

The National Human Genome Research Institute (NHGRI) has produced a series of fact sheets to provide an overview of the institute, explore the social implications of genetic research, and explain complex genetic concepts and research techniques to a non-scientific audience. Teachers, students and the general public alike will find the materials clearly written and easy to understand.
http://www.genome.gov/page.cfm?pageID=10000202

Deadly meningitis B, a disease that mainly targets children, has had its secrets laid bare by the latest genomic techniques.
positive implications of mapping the human genome...

The Genome Database
The public database of the Human Genome Project, which releases its latest findings on a daily basis to enable scientists around the world to advance their research.
http://gdbwww.gdb.org/

The Genome Database
This page contains a map of the GDB web site in a table with the GDB Home Page/Simple Search in the leftmost column. Links available from a location are shown to its right. The block shown in grey contains links to GDB help files..
http://gdbwww.gdb.org/gdb/siteMap.html

The Genome Database - Advanced Search Options
http://gdbwww.gdb.org/gdb/advancedSearch.html

The Genomics Lexicon
http://genomics.phrma.org/lexicon/

Biotechnology Information Directory - The WWW Virtual Library
Genomics, Proteomics, Drug Discovery and Drug Screening Companies - A public service of Cato Research Ltd. - This section contains, more or less, companies that provide genomics products, services and software.
http://www.cato.com/biotech/bio-genomics.html

BioExchange News - daily updated bio industry news
http://www.bioexchange.com/news/index.cfm

To get really blown away by what's online now
click on Tools in the above site, and then select
"web based" and scroll down to ...
"FlyBase - A Database of the Drosophila Genome"
http://flybase.bio.indiana.edu/
(my neuro, Dr. Jon Stoessl at UBC, studies these)

go to GOOGLE and search for "drosophila AND parkinson"
http://www.google.com/search?

check out...

Fly Model of Parkinson's Offers Hope of Simpler, Faster Research
http://www.nih.gov/news/NIH-Record/...

What we may gain from a Fly Diseases, Genomes and Genome Projects
http://www.andreasbender.de/

or... Flies Are US
http://www.molbio.princeton.edu/

Amazing Science - Drosophila Parkinson's
http://www.designcommunity.com/fireside/46.html

This e-mail is gettin' outa hand...

I'm runnin' off at the mouth like a "soup sandwich" ...

I hope the "key" came through...

How can The Human Genome Project help find a CURE for Parkinson's?

Well... the Human Genome Project and the fruit fly model allows scientists to study a lifetime of Parkinson's in 45 days and with cloning all stages of a mutant can be observed at once... whereas, a "lifetime" experiment with gene modification, would take years in a primate and possibly decades in a human. (I keep waiting the elusive "5 years"... I don't think I have "decades"...)

and... it's the Human Genome Project and the Global Exchange of "information" via the Internet that makes this all possible and very real... a student can contact a "Parkie", write an Award winning research paper... capeche?

Pay particular attention to Flys Are US

Read the entire site and all of it's links...

I hope the above is of some assistance...

Please let me know... and perhaps share a copy
of your research??

Take care, it's a "jungle" out there!
http://www.newscientist.com/news/news.jsp?id=ns99993168

Thank you xxxx, for the "spur" I needed to revisit
"Parkinson's & The Human Genome Project"

looks like it's time to revamp that page,
check for dead links and add a few new ones...

Have a nice DNA ........ murray



The animated fruit fly is a design cheerfully stolen from Flys Are US


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