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A Student's Question...
How can The Human Genome Project
help find a CURE for Parkinson's?
![[ Common Fruit Fly ]](fly.gif)
Drosophila: a fly geneticist's swiss army knife
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Adobe Acrobat reader ...)
Topic 10A: a student's question
This site contains education and research URL's bookmarked by a Parkinson's patient. Nothing you read in these pages should be considered an endorsement or medical advice. > Saturday, Dec. 14th. 2002 > > Hi Mr. Charters, > > My name is xxxx and I am an OAC student > at Thornlea Secondary School. > > I am researching how the human genome project > will help find a cure for Parkinson's disease. > > I would really appriciate it if you can give > me any information on this subject. > > Thank you very much, > xxxx Good Morning xxxx, Let's see... OAC student at TSS... The Ontario Education system includes the "OAC" year. OAC stands for Ontario Academic Credit, of which you need 6 to enter university. Sooo... you must be a Grade 12/OAC student working on your University Entrance... will you be going to Queens? Neurobiology? (do they have neurobiology at Queens?) Thornlea Secondary School 8075 Bayview Avenue Thornhill, Ontario L3T 4N4 Phone: (905) 889-9696 Facsimile number: (905) 889-2991 http://www.thornlea.ca/ Thornhill is a community of about 100,000 persons just on the north end of Toronto... my aunt lived in Orillia... I'm a 58 year old elevator / escalator mechanic who has Parkinson's... I still work every day... We live in Vancouver, BC I have a web site... Welcome to Parkinson's Resources! Dedicated to Parkinson's Awareness & FREE Easy Access to "Information" for All and it has a Parkinson's & Human Genome Project page... 010.html but... you must have seen that or you wouldn't have asked for my input... Read this "backgrounder" first... The Decade of the Brain : A Brief Review http://www.neurologyindia.com/vol48-3/ra63.pdf (requires Adobe Acrobat reader...) http://www.adobe.com/products/acrobat/... There was a mutation in the Alpha Synuclein gene... Gretchen, Vogel, Gene discovery offers tentative clues to Parkinson’s, Science, 06/27/97, Vol 276 Issue 5321, p1973, 1p 1c. Polymeropoulos, Michael H, et al., Mutation in the a-Synuclein Gene Identified in Families with Parkinson’s Disease, Science, 06/27/97, Vol 276 Issue 5321, p2045-47, 3p. http://www.sciencemag.org/content/ SCIENCE Online wants you to Sign In... AND PAY! That sucks... Want the same thing FREE? Yah! .... if you go back to ... 010.html and click on... Genes and Disease http://www.ncbi.nlm.nih.gov/disease/ you can follow this wealth of information... click on... http://www.ncbi.nlm.nih.gov/disease/Brain.html click on... http://www.ncbi.nlm.nih.gov/disease/Parkinson.html http://www.nhgri.nih.gov/DIR/LGDR/PARK2/ "Researchers from the National Human Genome Research Institute in Maryland have discovered a gene called alpha-synuclein that is the possible foundation in a heredity form of Parkinson’s." go to ... http://a-s.clayton.edu/hampikian/... and click on... Carpenter, Caryn Gene discovery offers tentative clues to Parkinson's http://a-s.clayton.edu/hampikian/1901H/ http://www.lancetneuronet.com/registration Registration is completely FREE and provides the following benefits: Unlimited search facilities Free access to selected full-text articles 'Pay per view' article access Free access to the Electronic Research Archive (ERA) Free full-text global news A wide range of subscription options Once you have registered to THE LANCET Publishing Group you do not need to register again. http://www.lancetneuronet.com/journal/vol1/iss5/contents http://www.lancetneuronet.com/... Search Lancet for "parkinson" AND "gene" http://www.lancetneuronet.com/search ahhh! 24 hits... full text available... Shaking the Family Tree: Discovery of Familial Parkinson's Disease Gene The Genetics of Parkinson's Disease Can 18F-Fluorodopa Positron Emission Tomography Help Determine Disease Status in Familial Parkinson's Disease? Motor Circuits and Dystonia Tuberous Sclerosis: Endocytosis and Growth Regulation Functional Imaging of Brain Mechanisms in Dopa-Induced Dyskinesia Nerve Growth Factor Gene Transfer to the Aging Brain: A Role in Preventing Dementia? A Possible Mouse Model of Huntington's Disease Pallidotomy: Refining the technique Alzheimer's Disease Pathology and Genetics The Broadening Image of ALS: Discovery of New Mutations Identifies Clinical Phenotypes Clinical and Pathological Variability and Similarity in Degenerative Disease With P301L Tau Mutations Pallidotomy for Dystonia: Why Should It Work? Rebuilding the brain from postmortem tissue: do we have the needed insights and technology? Apolipoprotein E and the Diagnosis of Alzheimer's Disease Radiological onset and progression of autosomal dominant Alzheimer's disease The Elusive Heredity of Tourette Syndrome Imaging the Limbic System: Clinical Implications Treatment of Restless Legs Syndrome Therapy for ALS and all free... are you "swamped" yet? The above articles are great but... they're typically a coupla years old... go to my VIP page... vip.html click on... PhRMA Genomics Today PhRMA Genomics Today http://genomics.phrma.org/today/ click on... Human Genome Project Genetics in the News http://www.ornl.gov/hgmis/archive/headlines.html Genetic Disease Information --pronto! http://www.ornl.gov/hgmis/medicine/assist.html Genomic News Network http://gnn.tigr.org/main.shtml Genetics and Genomics Timeline http://gnn.tigr.org/timeline/timeline_home.shtml Thomas Hunt Morgan, an embryologist who had turned to research in heredity, in 1907 began to extensively breed the common fruit fly, Drosophila melanogaster. He hoped to discover large-scale mutations that would represent the emergence of new species. As it turned out, Morgan confirmed Mendelian laws of inheritance and the hypothesis that genes are located on chromosomes. He thereby inaugurated classical experimental genetics. http://gnn.tigr.org/timeline/1910_Morgan.shtml What's a Genome? http://gnn.tigr.org/whats_a_genome/Chp1_1_1.shtml A Quick Guide to Sequenced Genomes http://gnn.tigr.org/sequenced_genomes/ The Other Human Genome Mitochondria are the focus of new research on Alzheimer’s, Parkinson’s and diabetes http://gnn.tigr.org/articles/04_02/mito_dna.shtml Human genome search implicates multiple genes in Parkinson’s http://exploration.vanderbilt.edu/news/ Human Genome Research Implicates Genes in Parkinson's http://my.webmd.com/content/article/ The National Human Genome Research Institute (NHGRI) created the Talking Glossary of Genetic Terms to help people without scientific backgrounds understand the terms and concepts used in genetic research. Simply click on the term of interest to open a page with a wealth of information, including the term's pronunciation, audio information, images and additional links to related terms. Students, teachers and parents will find the glossary an easy-to-use, always available learning source on genetics. Talking Glossary of Genetic Terms Guide to the Talking Glossary of Genetics http://www.genome.gov/page.cfm?pageID=10003803 Search PubMed for "genome AND parkinson" http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query? MEDLINEplus Latest Parkinson's News http://www.nlm.nih.gov/medlineplus/ Subject Index of Text Prepared for Human Genome News - 1995 to Present http://www.ornl.gov/hgmis/publicat/hgn/hgnarch.html Introduction to the Human Genome Project http://www.genome.gov/page.cfm?pageID=10001772 Online Genetics Resources for Educators and Students http://www.genome.gov/page.cfm?pageID=10000464 Welcome to the Human Genome Project, "Exploring Our Molecular Selves" online multimedia educational kit. http://www.genome.gov/Pages/Hyperion/educationkit/... The National Human Genome Research Institute (NHGRI) has produced a series of fact sheets to provide an overview of the institute, explore the social implications of genetic research, and explain complex genetic concepts and research techniques to a non-scientific audience. Teachers, students and the general public alike will find the materials clearly written and easy to understand. http://www.genome.gov/page.cfm?pageID=10000202 Deadly meningitis B, a disease that mainly targets children, has had its secrets laid bare by the latest genomic techniques. positive implications of mapping the human genome... The Genome Database The public database of the Human Genome Project, which releases its latest findings on a daily basis to enable scientists around the world to advance their research. http://gdbwww.gdb.org/ The Genome Database This page contains a map of the GDB web site in a table with the GDB Home Page/Simple Search in the leftmost column. Links available from a location are shown to its right. The block shown in grey contains links to GDB help files.. http://gdbwww.gdb.org/gdb/siteMap.html The Genome Database - Advanced Search Options http://gdbwww.gdb.org/gdb/advancedSearch.html The Genomics Lexicon http://genomics.phrma.org/lexicon/ Biotechnology Information Directory - The WWW Virtual Library Genomics, Proteomics, Drug Discovery and Drug Screening Companies - A public service of Cato Research Ltd. - This section contains, more or less, companies that provide genomics products, services and software. http://www.cato.com/biotech/bio-genomics.html BioExchange News - daily updated bio industry news http://www.bioexchange.com/news/index.cfm To get really blown away by what's online now click on Tools in the above site, and then select "web based" and scroll down to ... "FlyBase - A Database of the Drosophila Genome" http://flybase.bio.indiana.edu/ (my neuro, Dr. Jon Stoessl at UBC, studies these) go to GOOGLE and search for "drosophila AND parkinson" http://www.google.com/search? check out... Fly Model of Parkinson's Offers Hope of Simpler, Faster Research http://www.nih.gov/news/NIH-Record/... What we may gain from a Fly Diseases, Genomes and Genome Projects http://www.andreasbender.de/ or... Flies Are US http://www.molbio.princeton.edu/ Amazing Science - Drosophila Parkinson's http://www.designcommunity.com/fireside/46.html This e-mail is gettin' outa hand... I'm runnin' off at the mouth like a "soup sandwich" ... I hope the "key" came through... How can The Human Genome Project help find a CURE for Parkinson's? Well... the Human Genome Project and the fruit fly model allows scientists to study a lifetime of Parkinson's in 45 days and with cloning all stages of a mutant can be observed at once... whereas, a "lifetime" experiment with gene modification, would take years in a primate and possibly decades in a human. (I keep waiting the elusive "5 years"... I don't think I have "decades"...) and... it's the Human Genome Project and the Global Exchange of "information" via the Internet that makes this all possible and very real... a student can contact a "Parkie", write an Award winning research paper... capeche? Pay particular attention to Flys Are US Read the entire site and all of it's links... I hope the above is of some assistance... Please let me know... and perhaps share a copy of your research?? Take care, it's a "jungle" out there! http://www.newscientist.com/news/news.jsp?id=ns99993168 Thank you xxxx, for the "spur" I needed to revisit "Parkinson's & The Human Genome Project" looks like it's time to revamp that page, check for dead links and add a few new ones... Have a nice DNA ........ murray
The animated fruit fly is a design cheerfully stolen from
Flys Are US
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